(19)

(11)

EP 1 228 066 A2

(12)

(88) Date of publication A3: 27.12.2001 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00974509.2 (22) Date of filing: 02.11.2000

(51) International Patent Classification (IPC)7: C07D 405/12, C07D 409/12, C07D 471/04, A61K 31/47, A61P 25/00 // (C07D471/04, 221:00, 209:00) (86) International application number: PCT/EP0010/911 (87) International publication number: WO 0132/646 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.11.1999 GB 9926302 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9GS (GB)	(72) Inventors: BROMIDGE, Steven Mark,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) SERAFINOWSKA, Halina T.,SmithKline Beecham Phar. Harlow,Essex CM19 5AW (GB) (74) Representative: Valentine, Jill Barbara et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)