(19)

(11)

EP 1 228 088 A2

(12)

(88) Date of publication A3: 17.01.2002 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00975594.3 (22) Date of filing: 03.11.2000

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/US0030/533 (87) International publication number: WO 0132/696 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.11.1999 US 434784 (71) Applicant: The Burnham Institute La Jolla, CA 92037 (US)	(72) Inventors: ZAPATA, Juan, M. San Diego, CA 92122 (US) REED, John, C. Rancho Santa Fe, CA 92067 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)