(19)

(11)

EP 1 228 096 A1

(12)

(43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00975380.7 (22) Date of filing: 25.10.2000

(51) International Patent Classification (IPC)7: C07K 14/72, C07H 21/04, C12N 15/00, C12N 15/63, C12N 15/85, C12N 15/86, G01N 33/53 (86) International application number: PCT/US0029/426 (87) International publication number: WO 0132/710 (10.05.2001 Gazette 2001/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.10.1999 US 162264 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventors: TAN, Carina Rahway, NJ 07065-0907 (US) MCKEE, Karen Rahway, NJ 07065-0907 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)