(19)

(11)

EP 1 228 200 A1

(12)

(43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00975458.1 (22) Date of filing: 27.10.2000

(51) International Patent Classification (IPC)7: C12N 15/10, C12Q 1/68 // (C07K14/435, C12N9:02) (86) International application number: PCT/US0029/717 (87) International publication number: WO 0130/998 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.10.1999 US 161850 P 27.10.1999 US 161852 P 28.09.2000 US 672629 28.09.2000 US 672859 (71) Applicants: CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena,California 91125 (US) Arnold, Frances Pasadena, CA 91105 (US)	(72) Inventors: ARNOLD, Frances Pasadena, CA 91105 (US) SIEBER, Volker Pasadena, CA 91107 (US) ZHANG, Ji, Hu Hockessin, DE 19707 (US) (74) Representative: Howard, Paul Nicholas  Carpmaels & Ransford43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)