(19)

(11)

EP 1 228 201 A1

(12)

(43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00983130.6 (22) Date of filing: 13.11.2000

(51) International Patent Classification (IPC)7: C12N 15/10, C12N 15/11, C07H 21/04, A61K 31/713 (86) International application number: PCT/EP0011/197 (87) International publication number: WO 0136/624 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.11.1999 GB 9926810 10.05.2000 GB 0011126 (71) Applicant: Biovation Limited Aberdeen AB22 8GU (GB)	(72) Inventors: CARR, Frank J. BalmedieAberdeen AB23 8XU (GB) CARTER, Graham By NewmacharAberdeenshire AB21 7XB (GB) (74) Representative: Benz, Jürgen  Merck KGaA,Patentabteilung,Frankfurter Strasse 250 64293 Darmstadt 64293 Darmstadt (DE)