(19)

(11)

EP 1 228 204 A2

(12)

(88) Date of publication A3: 25.10.2001 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00965205.8 (22) Date of filing: 20.09.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, A01K 67/027, A61K 38/17, G01N 33/53 // C07K14/71 (86) International application number: PCT/US0025/790 (87) International publication number: WO 0121/794 (29.03.2001 Gazette 2001/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.09.1999 US 154846 P (71) Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH New York,New York 10158 (US)	(72) Inventors: ITOH, Fumiko S-751 24 Uppsala (SE) ITOH, Susumu S-751 24 Uppsala (SE) HELDIN, Carl-Henrik S-751 24 Uppsala (SE) TEN-DIJKE, Peter,Netherlands Cancer Institute NL-1066 CX Amsterdam (NL) (74) Representative: Harrison Goddard Foote  31 St Saviourgate York Y01 8NQ York Y01 8NQ (GB)