(19)

(11)

EP 1 228 215 A1

(12)

(43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00939889.2 (22) Date of filing: 14.06.2000

(51) International Patent Classification (IPC)7: C12N 15/19, C07K 14/52, C07K 16/24, G01N 33/68 (86) International application number: PCT/US0016/441 (87) International publication number: WO 0077/209 (21.12.2000 Gazette 2000/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.06.1999 US 333076 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: CONKLIN, Darrell, C. Seattle, WA 98102 (US) GAO, Zeren Redmond, WA 98052 (US) (74) Representative: Dean, John Paul et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)