(19)

(11)

EP 1 228 221 A2

(12)

(88) Date of publication A3: 28.02.2002 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00971299.3 (22) Date of filing: 27.10.2000

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 15/11, C12N 9/12, C07K 16/40, C12P 21/02, C12Q 1/68, A01K 67/027, G01N 33/68 (86) International application number: PCT/EP0009/498 (87) International publication number: WO 0131/029 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.10.1999 US 162307 P 07.02.2000 US 180525 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)	(72) Inventors: ALLEN, Janet Southall, Middlesex UB2 4LS (GB) GOSINK, Mark Bothell, WA 98011 (US) MELENDEZ, Alirio, J. Singapore 104001 (SG) TAKACS, Laszlo F-92340 Bourg-la-Reine (FR) (74) Representative: Dufresne, Guillaume Alain François et al Pfizer Global Research & DevelopmentFresnes Laboratories3-9, rue de la LogeB.P. 100 94265 Fresnes Cédex 94265 Fresnes Cédex (FR)