(19)

(11)

EP 1 228 230 A2

(12)

(88) Date of publication A3: 29.11.2001 (43) Date of publication: 07.08.2002 Bulletin 2002/32 (21) Application number: 00978570.0 (22) Date of filing: 09.11.2000

(51) International Patent Classification (IPC)7: C12N 15/82, A01N 65/00 (86) International application number: PCT/US0031/111 (87) International publication number: WO 0134/823 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.11.1999 US 165392 P (71) Applicant: University of South Carolina ColumbiaSouth Carolina 29208 (US)	(72) Inventors: PRUSS, Gail, J. Columbia, SC 29209 (US) VANCE, Vicki, B. Columbia, SC 29212 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)