(19)

(11)

EP 1 229 915 A1

(12)

(43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00978442.2 (22) Date of filing: 08.11.2000

(51) International Patent Classification (IPC)7: A61K 31/55, C07D 401/14, A61P 19/08, A61P 19/10 (86) International application number: PCT/US0030/758 (87) International publication number: WO 0134/160 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 10.11.1999 US 164562 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: MARQUIS, Robert, W., Jr. Wayne, PA 19087 (US) RU, Yu Wayne, PA 19087 (US) VEBER, Daniel, Frank Ambler, PA 19002 (US) (74) Representative: Morris, Miriam Elizabeth  GlaxoSmithKlineCorporate Intellectual Property980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)