(19)

(11)

EP 1 229 916 A2

(12)

(88) Date of publication A3: 10.05.2002 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00978360.6 (22) Date of filing: 03.11.2000

(51) International Patent Classification (IPC)7: A61K 31/555, A61K 31/335, A61P 35/00 // (A61K31/555, 31:335, 31:165),(A61K31/335, 31:165) (86) International application number: PCT/US0030/377 (87) International publication number: WO 0134/131 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.1999 US 164889 P 03.08.2000 US 222561 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)	(72) Inventors: MERRIMAN, Ronald, Lynn Ann Arbor, MI 48108 (US) KLOHS, Wayne, Daniel Ypsilanti, MI 48197 (US) (74) Representative: Tesch, Rudolf, Dr. et al Warner-Lambert Company,c/o Gödecke GmbH,Patents 79090 Freiburg 79090 Freiburg (DE)