(19)

(11)

EP 1 229 920 A1

(12)

(43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00977293.0 (22) Date of filing: 29.09.2000

(51) International Patent Classification (IPC)7: A61K 31/70 (86) International application number: PCT/US0041/038 (87) International publication number: WO 0122/970 (05.04.2001 Gazette 2001/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.09.1999 US 156542 P (71) Applicant: THE CLEVELAND CLINIC FOUNDATION Cleveland, OH 44195 (US)	(72) Inventors: SILVERMAN, Robert, H. Beachwood, OH 44120 (US) RUSCH, Lorraine Elmsford, NY 10523 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)