(19)

(11)

EP 1 230 210 A1

(12)

(43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00974972.2 (22) Date of filing: 13.11.2000

(51) International Patent Classification (IPC)7: C07C 217/60, C07C 217/62, C07C 217/72, C07D 209/14, C07D 213/61, A61K 31/135, A61K 31/44, A61K 31/415 (86) International application number: PCT/JP0008/007 (87) International publication number: WO 0136/375 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 16.11.1999 AU PQ407699 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shiOsaka 541-8514 (JP)

(72) Inventors: TANIGUCHI, Kiyoshi,Fujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) KAYAKIRI, Hiroshi,Fujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) FUJII, Naoaki San Francisco,CA 94131 (US) HAMASHIMA, Hitoshi,Fujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) SAKURAI, MinoruFujisawa Pharmaceutical Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) WASHIZUKA, KenichiFujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) TOMISHIMA, Yasuyo,Fujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) HAMADA, KaoriFujisawa Pharmaceutical Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) YAMAMOTO, Nobuhiro,Fujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) ISHIKAWA, HirofumiFujisawa Pharma. Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) TANIMURA, NaokoFujisawa Pharmaceutical Co., Ltd. Osaka-shi,Osaka 541-8514 (JP) (74) Representative: Gille Hrabal Struck Neidlein Prop Roos  Patentanwälte,Brucknerstrasse 20 40593 Düsseldorf 40593 Düsseldorf (DE)