(19)
(11) EP 1 230 225 A2

(12)

(88) Date of publication A3:
08.11.2001

(43) Date of publication:
14.08.2002 Bulletin 2002/33

(21) Application number: 00971987.3

(22) Date of filing: 19.10.2000
(51) International Patent Classification (IPC)7C07D 239/94, C07D 239/95, C07D 471/04, C07D 491/04, C07D 495/04, C07D 239/46, A61K 31/517, A61P 25/18
(86) International application number:
PCT/US0026/261
(87) International publication number:
WO 0132/632 (10.05.2001 Gazette 2001/19)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 01.11.1999 US 162900 P

(71) Applicant: ELI LILLY AND COMPANY
Indianapolis, Indiana 46285 (US)

(72) Inventors:
  • AMBLER, Samantha Jayne
    Sandhurst,Berkshire GU47 0YS (GB)
  • BAKER, Stephen Richard
    Yateley,Hampshire GU46 6DQ (GB)
  • CLARK, Barry Peter
    Lower Froyle,Hampshire GU34 4LX (GB)
  • COLEMAN, Darrell, Stephen
    Cary, NC 27513 (US)
  • FOGLESONG, Robert, James
    Durham, NC 27712 (US)
  • GOLDSWORTHY, John
    Basingstoke,Hampshire RG24 9JW (GB)
  • JAGDMANN, Gunnar, Erik, Junior
    Apex, NC 27502 (US)
  • JOHNSON, Kirk, Willis
    Carmel, IN 46032 (US)
  • KINGSTON, Ann, Elizabeth
    Indianapolis, IN 46268 (US)
  • OWTON, William Martin
    Lightwater,Surrey GU18 5XX (GB)
  • SCHOEPP, Darryle, Darwin
    Indianapolis, IN 46202 (US)
  • HONG, Jian, Eric
    Carmel, IN 46033 (US)
  • SCHKERYANTZ, Jeffrey, Michael
    Fishers, IN 46038 (US)
  • VANNIEUWENHZE, Michael, Scott
    Indianapolis, IN 46236 (US)
  • ZIA-EBRAHIMI, Mohammad, Sadegh
    Indianapolis, IN 46254 (US)

(74) Representative: Pritchard, Judith et al
Eli Lilly and Company LimitedEuropean Patent OperationsErl Wood Manor
Windlesham, Surrey GU20 6PH
Windlesham, Surrey GU20 6PH (GB)

   


(54) PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES