(19)

(11)

EP 1 230 361 A2

(12)

(88) Date of publication A3: 06.06.2002 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00978278.0 (22) Date of filing: 27.10.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/63, C07K 14/72, C07K 16/28, C07K 16/42, C12N 5/20, G01N 33/542, G01N 33/68, A61P 25/00, C12Q 1/68 (86) International application number: PCT/US0029/601 (87) International publication number: WO 0131/014 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.10.1999 US 427653 27.10.1999 US 427859 27.10.1999 US 428020 27.10.1999 US 428114 28.10.1999 US 429695 28.10.1999 US 429676 28.10.1999 US 429555 28.10.1999 US 429517 03.12.1999 US 454399 12.01.2000 US 481794 (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)

(72) Inventors: VOGELI, Gabriel Seattle, WA 98119 (US) WOOD, Linda, S. Portage, MI 49024 (US) MERCHANT, Kalpana Portage, MI 49024 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)