(19)

(11)

EP 1 230 362 A2

(12)

(88) Date of publication A3: 22.11.2001 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00978641.9 (22) Date of filing: 14.11.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, C12Q 1/68, G01N 33/53, C12N 15/62 (86) International application number: PCT/US0031/278 (87) International publication number: WO 0136/465 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.11.1999 US 442164 25.02.2000 US 511879 19.04.2000 US 552203 07.06.2000 US 210332 P (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: SHEPPARD, Paul, O. Granite Falls, WA 98252 (US) BISHOP, Paul, D. Fall City, WA 98024 (US) WHITMORE, Theodore, E. Redmond, WA 98052 (US) THOMPSON, Penny, P. Snohomish, WA 98290 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)