(19)

(11)

EP 1 230 365 A2

(12)

(88) Date of publication A3: 22.11.2001 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00979198.9 (22) Date of filing: 17.11.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C12N 5/10, C07K 14/705, C07K 16/28, G01N 33/50 (86) International application number: PCT/US0031/674 (87) International publication number: WO 0136/639 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.11.1999 US 166285 P 21.09.2000 US 234099 P (71) Applicant: PIONEER HI-BRED INTERNATIONAL, INC. Des Moines, Iowa 50309 (US)	(72) Inventors: FLANNAGAN, Ronald, D. Grimes, IA 50111 (US) MATHIS, John, P. Des Moines, IA 50313 (US) MEYER, Terry, EuClaire Urbandale, IA 50322 (US) (74) Representative: Irvine, Jonquil Claire  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)