(19)

(11)

EP 1 230 370 A2

(12)

(88) Date of publication A3: 29.11.2001 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00978769.8 (22) Date of filing: 17.11.2000

(51) International Patent Classification (IPC)7: C12N 15/19, C07K 14/52, C07K 16/24, C12N 1/21, G01N 33/68, C12Q 1/68, A61K 48/00, A61K 39/395, A61K 31/70 (86) International application number: PCT/US0031/629 (87) International publication number: WO 0136/644 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.11.1999 US 166177 P 16.11.2000 US  (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)	(72) Inventors: RASTELLI, Luca Guilford, CT 06437 (US) LEWIN, David New Haven, CT 06511 (US) TAILLON, Bruce Middletown, CT 06457 (US) ANDREW, David, P. Branford, CT 06405 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)