(19)

(11)

EP 1 230 372 A2

(12)

(88) Date of publication A3: 18.04.2002 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00977200.5 (22) Date of filing: 13.11.2000

(51) International Patent Classification (IPC)7: C12N 15/29, C12N 15/82, C12N 15/11, C12N 9/02, C07K 14/415, A01H 5/00 (86) International application number: PCT/US0031/187 (87) International publication number: WO 0136/464 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.11.1999 US 166128 P 03.05.2000 US 201837 P (71) Applicants: PIONEER HI-BRED INTERNATIONAL, INC. Des Moines, Iowa 50309 (US) Curagen Corporation New Haven, CT 06511 (US)	(72) Inventors: BIDNEY, Dennis, L. Urbandale, IA 50322 (US) DUVICK, Jonathan, P. Des Moines, IA 50310 (US) HENDRICK, Carol Des Moines, IA 50310 (US) HU, Xu Urbandale, IA 50322 (US) LU, Guihua Urbandale, IA 50322 (US) CRASTA, Oswald, R. Branford, CT 06405 (US) (74) Representative: Irvine, Jonquil Claire et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)