(19)

(11)

EP 1 230 374 A2

(12)

(88) Date of publication A3: 17.01.2002 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00973191.0 (22) Date of filing: 02.11.2000

(51) International Patent Classification (IPC)7: C12N 15/63, C07K 19/00 (86) International application number: PCT/IL0000/708 (87) International publication number: WO 0134/091 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.11.1999 US 164140 P 18.11.1999 US 166389 P (71) Applicants: YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM 91390 Jerusalem (IL) Yissum Research and Development Company of the Hebrew University of Jerusalem 91042 Jerusalem (IL)

(72) Inventors: LEVY, Ilan 79830 Kfar Hari"f (IL) NUSSINOVITCH, Amos 76566 Rehovot (IL) SHOSEYOV, Oded 72910 Karme Yossef (IL) (74) Representative: Schmitz, Jean-Marie et al Dennemeyer & Associates SàrlP.O. Box 1502 1015 Luxembourg 1015 Luxembourg (LU)