(19)

(11)

EP 1 230 378 A2

(12)

(88) Date of publication A3: 22.11.2001 (43) Date of publication: 14.08.2002 Bulletin 2002/33 (21) Application number: 00978753.2 (22) Date of filing: 14.11.2000

(51) International Patent Classification (IPC)7: C12N 15/86, A61K 48/00 (86) International application number: PCT/US0031/590 (87) International publication number: WO 0136/650 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.11.1999 US 165638 P (71) Applicant: ONYX PHARMACEUTICALS, INC. Richmond, CA 94806 (US)	(72) Inventors: JOHNSON, Leisa Lafayette, CA 94549 (US) FATTAEY, Ali San Francisco, CA 94115 (US) HERMISTON, Terry Corte Madera, CA 94925 (US) (74) Representative: Cripps, Joanna Elizabeth et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)