(19)

(11)

EP 1 232 149 A2

(12)

(88) Date of publication A3: 08.11.2001 (43) Date of publication: 21.08.2002 Bulletin 2002/34 (21) Application number: 00988747.2 (22) Date of filing: 23.11.2000

(51) International Patent Classification (IPC)7: C07D 277/28, C07D 277/24, A01N 43/28 (86) International application number: PCT/EP0011/643 (87) International publication number: WO 0103/8317 (31.05.2001 Gazette 2001/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.11.1999 US 449143 (71) Applicant: Gesellschaft für BiotechnologischeForschung mbH (GBF) 38124 Braunschweig (DE)	(72) Inventors: MEYER, Oliver 55218 Ingelheim (DE) SIMON, Werner 55595 Hueffelsheim (DE) HOEFLE, Gerhard 38124 Braunschweig (DE) SOEKER, Udo D-38124 Braunschweig (DE) (74) Representative: Boeters, Hans Dietrich, Dr.  Patentanwälte Boeters & Bauer,Bereiteranger 15 81541 München 81541 München (DE)