(19)

(11)

EP 1 232 185 A2

(12)

(88) Date of publication A3: 18.10.2001 (43) Date of publication: 21.08.2002 Bulletin 2002/34 (21) Application number: 00977216.1 (22) Date of filing: 15.11.2000

(51) International Patent Classification (IPC)7: C07K 16/28, C07K 14/715, G01N 33/68, A61P 35/04 (86) International application number: PCT/US0031/230 (87) International publication number: WO 0103/8352 (31.05.2001 Gazette 2001/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.11.1999 US 449060 14.08.2000 US 225562 P (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)	(72) Inventors: MUELLER, Anja Palo Alto, CA 94306 (US) ZLOTNIK, Albert Palo Alto, CA 94306 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)