(19)

(11)

EP 1 232 246 A1

(12)

(43) Date of publication: 21.08.2002 Bulletin 2002/34 (21) Application number: 00980623.3 (22) Date of filing: 21.11.2000

(51) International Patent Classification (IPC)7: C12N 5/06, C12N 5/08, A61K 39/395, A61P 35/00, A61K 38/17, A61K 47/48, A61K 39/00 // C12Q1:02 (86) International application number: PCT/US0031/968 (87) International publication number: WO 0103/8496 (31.05.2001 Gazette 2001/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.11.1999 US 167394 P 22.12.1999 US 171546 P (71) Applicant: IMMUNEX CORPORATION SeattleWashington 98101 (US)	(72) Inventors: GALIBERT, Laurent, J. Seattle, WA 98115 (US) BORGES, Luis Seattle, WA 98107 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)