(19)

(11)

EP 1 232 247 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 21.08.2002 Bulletin 2002/34 (21) Application number: 00991029.0 (22) Date of filing: 22.11.2000

(51) International Patent Classification (IPC)7: C12N 5/06, C07K 14/00 (86) International application number: PCT/US0042/233 (87) International publication number: WO 0103/8344 (31.05.2001 Gazette 2001/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.11.1999 US 167438 P (71) Applicant: Graupner, Gerhart San Diego, CA 92124 (US)	(72) Inventor: Graupner, Gerhart San Diego, CA 92124 (US) (74) Representative: HOFFMANN - EITLE  Patent- und RechtsanwälteArabellastrasse 4 81925 München 81925 München (DE)