(19)

(11)

EP 1 232 258 A1

(12)

(43) Date of publication: 21.08.2002 Bulletin 2002/34 (21) Application number: 00967885.5 (22) Date of filing: 12.10.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/30, A61K 38/17, A61K 48/00, C12Q 1/68, G01N 33/574 (86) International application number: PCT/EP0010/228 (87) International publication number: WO 0102/9214 (26.04.2001 Gazette 2001/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.10.1999 GB 9924529 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE)	(72) Inventors: VINALS Y DE BASSOLS, Carlota B-1330 Rixensart (BE) GAULIS, Swann,Roman, Jean-Thomas B-1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)