(19)

(11)

EP 1 232 261 A2

(12)

(88) Date of publication A3: 17.01.2002 (43) Date of publication: 21.08.2002 Bulletin 2002/34 (21) Application number: 00973600.0 (22) Date of filing: 17.10.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/85, C07K 14/47, C12Q 1/68, G01N 33/50 (86) International application number: PCT/US0028/686 (87) International publication number: WO 0103/6619 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.11.1999 US 165221 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)	(72) Inventors: BAUMANN, Christian, A. Ann Arbor, MI 48105 (US) RIBON, Vered Ann Arbor, MI 48105 (US) SALTIEL, Alan, Robert Ann Arbor, MI 48105 (US) (74) Representative: Tesch, Rudolf, Dr. et al Warner-Lambert Company,c/o Gödecke GmbH,Patents 79090 Freiburg 79090 Freiburg (DE)