(19)

(11)

EP 1 233 772 A1

(12)

(43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00979177.3 (22) Date of filing: 14.11.2000

(51) International Patent Classification (IPC)7: A61K 31/69 (86) International application number: PCT/US0031/354 (87) International publication number: WO 0103/5966 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.11.1999 US 166938 P (71) Applicant: Topgene, Inc. Fullerton, CA 92835 (US)	(72) Inventor: MILJKOVIC, Dusan San Diego, CA 92122 (US) (74) Representative: Dokter, Eric-Michael  Anwaltskanzlei,Viering, Jentschura & Partner,Steinsdorferstrasse 6 80538 München 80538 München (DE)