(19)

(11)

EP 1 233 776 A1

(12)

(43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00980841.1 (22) Date of filing: 29.11.2000

(51) International Patent Classification (IPC)7: A61K 38/10, A61K 38/12, C07K 7/06, C07K 7/50, C07K 7/64 (86) International application number: PCT/US0032/407 (87) International publication number: WO 0103/7856 (31.05.2001 Gazette 2001/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 29.11.1999 US 167960 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: DHANAK, Dashyant West Chester, PA 19380 (US) KNIGHT, Steven, D. West Chester, PA 19380 (US) WARREN, Gregory, L. Parkerford, PA 19457 (US) (74) Representative: Hockley, Siân Catherine et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)