(19)

(11)

EP 1 233 942 A2

(12)

(88) Date of publication A3: 21.03.2002 (43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00992552.0 (22) Date of filing: 30.11.2000

(51) International Patent Classification (IPC)7: C07C 401/00 (86) International application number: PCT/US0042/393 (87) International publication number: WO 0104/2205 (14.06.2001 Gazette 2001/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.12.1999 US 168501 P 14.04.2000 US 197827 P 01.06.2000 US 208632 P 11.09.2000 US 231906 P (71) Applicant: THE PENN STATE RESEARCH FOUNDATION University Park, PA 16802 (US)	(72) Inventor: CANTORNA, Margherita, T. State College, PA 16802 (US) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)