(19)

(11)

EP 1 233 977 A1

(12)

(43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00980868.4 (22) Date of filing: 30.11.2000

(51) International Patent Classification (IPC)7: C07H 21/02, C12N 15/00, C12N 5/00, C07K 1/00, C07K 16/00 (86) International application number: PCT/US0032/521 (87) International publication number: WO 0104/0247 (07.06.2001 Gazette 2001/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 01.12.1999 US 452140 (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: KUMAR, Sanjay Audubon, PA 19403 (US) MCDONNELL, Peter, C. Thousand Oaks, CA 91320 (US) YOUNG, Peter, R. Wilmington, DE 19803 (US) (74) Representative: Connell, Anthony Christopher  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)