(19)

(11)

EP 1 234 021 A2

(12)

(88) Date of publication A3: 29.11.2001 (43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00972510.2 (22) Date of filing: 27.10.2000

(51) International Patent Classification (IPC)7: C12N 5/06, C12N 5/08, C12N 5/10, A01K 67/00 (86) International application number: PCT/CA0001/283 (87) International publication number: WO 0103/0980 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.10.1999 US 161797 P (71) Applicants: Mount Sinai Hospital TorontoOntario M5G 1X5 (CA) The General Hospital Corporation doing Business as Massachusetts General Hospital Boston, MA 02113 (US)	(72) Inventors: CASPER, Robert, F. Toronto, Ontario M4W 3B7 (CA) ROGERS, Ian Toronto, Ontario M5R 2K1 (CA) TILLY, Jonathan Windham, New Hampshire 03087 (US) JURISICOVA, Andrea Richmond Hill, Ontario L4C 4K9 (CA) PEREZ, Gloria, I. Malden, MA 02148 (US) (74) Representative: Holliday, Louise Caroline  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)