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EP 1 234 037 A2

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(88) Date of publication A3: 10.05.2002 (43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00992356.6 (22) Date of filing: 29.11.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 5/10, C07K 16/18, A61K 47/48, G01N 33/68, C12N 15/11, A61K 31/7088, C12N 15/62 // A61P13/08 (86) International application number: PCT/US0042/295 (87) International publication number: WO 0104/2472 (14.06.2001 Gazette 2001/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.11.1999 US 168182 P 21.11.2000 US 718159 (71) Applicant: SCHERING AKTIENGESELLSCHAFT 13342 Berlin (DE)

(72) Inventors: HARKINS, Richard Alameda, CA 94502 (US) LIN, Richard, J. Danville, CA 94526 (US) LUKE, May San Francisco, CA 94116 (US) MONTECLARO, Felipe Fremont, CA 94539 (US) PARKES, Deborah Hayward, CA 94541 (US) PARRY, Gordon Walnut Creek, CA 94596 (US) STEINBRECHER, Renate Walnut Creek, CA 94596 (US) VAN HEUIT, Pamela, Toy Moraga, CA 94556 (US) XUAN, Jian-Ai Castro Valley, CA 94591 (US) (74) Representative: Weiss, Wolfgang, Dipl.-Chem. Dr. et al Weickmann & WeickmannPatentanwältePostfach 86 08 20 81635 München 81635 München (DE)