(19)

(11)

EP 1 234 038 A1

(12)

(43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00978773.0 (22) Date of filing: 17.11.2000

(51) International Patent Classification (IPC)7: C12N 15/16, C12N 15/62, C12N 5/10, C07K 14/605, C07K 14/655, C12P 21/06 (86) International application number: PCT/US0031/634 (87) International publication number: WO 0103/6643 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.11.1999 US 166508 P (71) Applicant: TRANSKARYOTIC THERAPIES, INC. Cambridge, MA 02139 (US)	(72) Inventors: Treco, Douglas A. Arlington, MA 02476 (US) Concino, Michael F. Bolton, MA 01740 (US) Duguay, Stephen, J. Boston, MA 02114 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)