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(11)

EP 1 234 042 A1

(12)

(43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00973836.0 (22) Date of filing: 25.10.2000

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 15/63, C12N 9/64, C07K 16/40, C12Q 1/37 (86) International application number: PCT/US0029/380 (87) International publication number: WO 0103/1034 (03.05.2001 Gazette 2001/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.10.1999 US 426282 (71) Applicant: Millennium Pharmaceuticals, Inc. Cambridge,Massachusetts 02139 (US)	(72) Inventors: KAPELLER-LIBERMANN, Rosana Chestnut Hill, MA 02467 (US) WHITE, David Braintree, MA 02184 (US) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO.,Gray's Inn,14 South Square London WC1R 5JJ London WC1R 5JJ (GB)