(19)

(11)

EP 1 234 179 A2

(12)

(88) Date of publication A3: 17.01.2002 (43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00979803.4 (22) Date of filing: 04.12.2000

(51) International Patent Classification (IPC)7: G01N 33/53, G01N 33/68, C12N 15/10, C07K 1/04 (86) International application number: PCT/GB0004/629 (87) International publication number: WO 0104/0312 (07.06.2001 Gazette 2001/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.12.1999 GB 9928789 (71) Applicant: Domantis Limited London W1N 4AL (GB)	(72) Inventors: HOLT, Lucy Jessica Cambridge CB2 2JE (GB) DE WILDT, Rudolf, Maria, Theodora Cambridge CB3 9AU (GB) TOMLINSON, Ian Cambridge CB2 5LJ (GB) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)