(19)

(11)

EP 1 234 480 A2

(12)

(88) Date of publication A3: 31.01.2002 (43) Date of publication: 28.08.2002 Bulletin 2002/35 (21) Application number: 00968722.9 (22) Date of filing: 05.10.2000

(51) International Patent Classification (IPC)7: H04R 25/00, A61B 5/12 (86) International application number: PCT/US0027/460 (87) International publication number: WO 0102/6420 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.10.1999 US 157775 P (71) Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION Fort Collins, CO 80522 (US)	(72) Inventors: BURLEIGH, Joan, Marie Fort Collins, CO 80525 (US) THOMPSON, Michael, Wayne Waco, TX 76712 (US) JAMES, Susan, Patricia Bellvue, CO 80512 (US) PETERSON, Michael, Leroy, Jr. Orono, ME 04473 (US) (74) Representative: Kador & Partner  Corneliusstrasse 15 80469 München 80469 München (DE)