(19)

(11)

EP 1 235 576 A2

(12)

(88) Date of publication A3: 21.03.2002 (43) Date of publication: 04.09.2002 Bulletin 2002/36 (21) Application number: 00979767.1 (22) Date of filing: 28.11.2000

(51) International Patent Classification (IPC)7: A61K 31/50 (86) International application number: PCT/GB0004/532 (87) International publication number: WO 0104/1749 (14.06.2001 Gazette 2001/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.12.1999 GB 9929039 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)	(72) Inventors: GUTTERMAN, Donna Research Triangle Park, NC 27709 (US) SALONEN, Reijo Juhani Research Triangle Park, NC 27709 (US) (74) Representative: Reed, Michael Antony  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)