(19)

(11)

EP 1 235 577 A2

(12)

(88) Date of publication A3: 04.10.2001 (43) Date of publication: 04.09.2002 Bulletin 2002/36 (21) Application number: 00975608.1 (22) Date of filing: 08.11.2000

(51) International Patent Classification (IPC)7: A61K 31/55, C07D 409/14, A61P 19/08, A61P 19/10 (86) International application number: PCT/US0030/633 (87) International publication number: WO 0103/4565 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 10.11.1999 US 164511 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: MARQUIS, Robert, W., Jr. Wayne, PA 19087 (US) RU, Yu Wayne, PA 19087 (US) VEBER, Daniel, Frank Ambler, PA 19002 (US) (74) Representative: Walker, Ralph Francis, Dr. et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)