(19)

(11)

EP 1 235 908 A2

(12)

(88) Date of publication A3: 25.04.2002 (43) Date of publication: 04.09.2002 Bulletin 2002/36 (21) Application number: 00982559.7 (22) Date of filing: 08.12.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, G01N 33/53, C12Q 1/68, G01N 33/68, G01N 33/50, A61K 38/17 (86) International application number: PCT/US0033/463 (87) International publication number: WO 0104/2471 (14.06.2001 Gazette 2001/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.12.1999 US 169887 P 10.12.1999 US 170230 P (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)	(72) Inventors: PRAYAGA, Sudhirdas, K. Chesterfield, MO 63017 (US) SHIMKETS, Richard, A. West Haven, CT 06516 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)