(19)

(11)

EP 1 235 910 A1

(12)

(43) Date of publication: 04.09.2002 Bulletin 2002/36 (21) Application number: 00972153.1 (22) Date of filing: 13.10.2000

(51) International Patent Classification (IPC)7: C12N 15/40, C12N 15/62, C12N 7/01, C07K 14/08, A61K 39/00 (86) International application number: PCT/US0028/430 (87) International publication number: WO 0102/7282 (19.04.2001 Gazette 2001/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.10.1999 GB 9924352 (71) Applicant: THE DOW CHEMICAL COMPANY Midland, Michigan 48674 (US)	(72) Inventors: HELLENDOORN, Koen Cambridge,Suffolk CB8 7AT (GB) JONES, Tim Cambridge CB2 4AJ (GB) (74) Representative: Raynor, John  W.H. Beck, Greener & Co7 Stone BuildingsLincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)