(19)

(11)

EP 1 237 546 A2

(12)

(88) Date of publication A3: 11.07.2002 (43) Date of publication: 11.09.2002 Bulletin 2002/37 (21) Application number: 00965517.6 (22) Date of filing: 29.09.2000

(51) International Patent Classification (IPC)7: A61K 31/00, A61K 31/47, A61K 31/4709, A61K 31/497, A61K 31/473, A61K 31/4184, A61K 31/122, A61K 31/196, C07D 215/52, A61P 31/14, A61K 38/21, A61K 31/711, A61K 31/343, A61K 31/437 // A61K38:21, A61K31:00, A61K31:711, A61K31:00, A61K31:437, A61K31:00, A61K31:343, A61K31:00 (86) International application number: PCT/US0026/797 (87) International publication number: WO 0102/4785 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.10.1999 US 157017 P (71) Applicant: Institute of Molecular and Cell Biology Singapore 117609 (SG)	(72) Inventors: TAN, Yin, Hwee Singapore 117609 (SG) DRISCOLL, John, Stanford Rockville, MD 20854 (US) MUI MUI, Sim Singapore 117609 (SG) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO.Gray's Inn14 South Square London WC1R 5JJ London WC1R 5JJ (GB)