(19)

(11)

EP 1 237 559 A1

(12)

(43) Date of publication: 11.09.2002 Bulletin 2002/37 (21) Application number: 00982033.3 (22) Date of filing: 29.11.2000

(51) International Patent Classification (IPC)7: A61K 31/7076, A61K 31/727, A61P 7/02 (86) International application number: PCT/SE0002/378 (87) International publication number: WO 0103/9781 (07.06.2001 Gazette 2001/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.12.1999 SE 9904377 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: DIXON, John Loughborough, Leics. LE11 5RH (GB) HUMPHRIES, Robert Loughborough, Leics. LE11 5RH (GB) JARVIS, Gavin Oxford OX1 3QT (GB) KIRK, Ian Bakewell RoaAstraZeneca R & D Charnwood (GB)