(19)

(11)

EP 1 237 592 A1

(12)

(43) Date of publication: 11.09.2002 Bulletin 2002/37 (21) Application number: 00938222.7 (22) Date of filing: 08.06.2000

(51) International Patent Classification (IPC)7: A61M 5/00 (86) International application number: PCT/US0015/751 (87) International publication number: WO 0007/4749 (14.12.2000 Gazette 2000/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.06.1999 US 330428 (71) Applicant: The Trustees of Columbia University in the City of New York New York, NY 10027-6699 (US)	(72) Inventor: SCHWARTZ, Arthur, E. Englewood, NJ 07631 (US) (74) Representative: Ruschke, Hans Edvard, Dipl.-Ing.  Ruschke Hartmann BeckerPienzenauerstrasse 2 81679 München 81679 München (DE)