(19)

(11)

EP 1 237 923 A2

(12)

(88) Date of publication A3: 21.02.2002 (43) Date of publication: 11.09.2002 Bulletin 2002/37 (21) Application number: 00984339.2 (22) Date of filing: 14.12.2000

(51) International Patent Classification (IPC)7: C07K 14/705, C12N 15/12, C12N 5/10, C12N 15/86, C12N 15/11, C12Q 1/68, A61K 38/17, C07K 16/28, G01N 33/53, A61P 25/00 (86) International application number: PCT/US0033/829 (87) International publication number: WO 0104/4283 (21.06.2001 Gazette 2001/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.12.1999 US 460602 (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventors: ROBERDS, Steven, L. Mattawan, MI 49071 (US) KARNOVSKY, Alla, M. Kalamazoo, MI 49009 (US) RUBLE, Cara, L. Paw Paw, MI (US) BENJAMIN, Christopher, W. Kalamazoo, MI 49009 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)