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EP 1 238 078 A2

(12)

(88) Date of publication A3: 03.01.2002 (43) Date of publication: 11.09.2002 Bulletin 2002/37 (21) Application number: 00986460.4 (22) Date of filing: 13.12.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 16/28, C12N 1/21, C12Q 1/68, G01N 33/68, A61K 38/17, A61K 39/395 (86) International application number: PCT/US0034/151 (87) International publication number: WO 0104/2294 (14.06.2001 Gazette 2001/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.12.1999 US 170453 P 14.01.2000 US 176195 P 14.02.2000 US 182296 P 11.04.2000 US 196460 P 11.04.2000 US 196528 P 11.04.2000 US 196527 P 11.04.2000 US 196267 P 11.04.2000 US 547276 13.10.2000 US 240543 P 13.10.2000 US 240539 P 13.10.2000 US 240503 P 13.10.2000 US 240508 P (71) Applicant: Arbor Vita Corporation Sunnyvale, CA 94086 (US)

(72) Inventors: LU, Peter Mountain View, CA 94043 (US) GARMAN, Jonathan, David San Jose, CA 95130 (US) CANDIA, Albert, Frederick, III Menlo Park, CA 94025 (US) (74) Representative: Walton, Seán Malcolm et al MEWBURN ELLIS,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)