(19)

(11)

EP 1 238 281 A2

(12)

(88) Date of publication A3: 18.04.2002 (43) Date of publication: 11.09.2002 Bulletin 2002/37 (21) Application number: 00982348.5 (22) Date of filing: 01.12.2000

(51) International Patent Classification (IPC)7: G01N 33/574, C12Q 1/68, G01N 33/68, G01N 33/58, A61P 35/00, A61K 39/00, C07K 16/18, A61K 47/48, C12N 15/12, C12N 15/63, C12N 5/10, A61K 39/395, A61K 31/7088 (86) International application number: PCT/US0032/750 (87) International publication number: WO 0104/0271 (07.06.2001 Gazette 2001/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 01.12.1999 US 168353 P 26.04.2000 US 559013 (71) Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH New York,New York 10158 (US)	(72) Inventors: ONO, Toshiro,Okayama University Medical School Okayama 700-8558 (JP) NAKAYAMA, EiichiOkayama University Medical School Okayama 700-8558 (JP) (74) Representative: Harrison Goddard Foote  31 St Saviourgate York Y01 8NQ York Y01 8NQ (GB)