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(11)

EP 1 240 178 A2

(12)

(88) Date of publication A3: 30.05.2002 (43) Date of publication: 18.09.2002 Bulletin 2002/38 (21) Application number: 00989432.0 (22) Date of filing: 22.12.2000

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C07K 14/00, C12N 1/21, C12N 9/00, C12N 15/00, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US0035/061 (87) International publication number: WO 0105/3456 (26.07.2001 Gazette 2001/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.12.1999 US 471275 21.01.2000 US 488725 25.01.2000 US 491404 25.04.2000 US 552317 17.06.2000 US 596196 31.08.2000 US 643313 (71) Applicant: HYSEQ, INC. Sunnyville, CA 94086 (US)

(72) Inventors: HALEY, Dana, A. San Jose, CA 95125 (US) BOYLE, Bryan, J. San Francisco, CA 94116 (US) SUK-YUE HO, Alice Union City, CA 94587 (US) ZHOU, Ping San Jose, CA 95132 (US) MIZE, Nancy, K. Mountain View, CA 94041 (US) KUO, Chiauyun San Jose, CA 95132 (US) ARTERBURN, Matthew, C. Pleasanton, CA 94566 (US) TANG, Y., Tom San Jose, CA 95118 (US) LIU, Chenghua San Jose, CA 95117 (US) DRMANAC, Radoje Palo Alto, CA 94303 (US) (74) Representative: Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem. et al Boeters & Bauer,Bereiteranger 15 81541 München 81541 München (DE)