(19)

(11)

EP 1 240 199 A2

(12)

(88) Date of publication A3: 10.01.2002 (43) Date of publication: 18.09.2002 Bulletin 2002/38 (21) Application number: 00993643.6 (22) Date of filing: 05.12.2000

(51) International Patent Classification (IPC)7: C07K 14/705, G01N 33/566, G01N 33/68, A61K 38/17, A61P 3/04 (86) International application number: PCT/GB0004/631 (87) International publication number: WO 0104/8483 (05.07.2001 Gazette 2001/27)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.12.1999 US 169944 P (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: BRENNAND, John Charles Macclesfield,Cheshire SK10 4TG (GB) CHARLES, Andrew David Macclesfield,Cheshire SK10 4TG (GB) HART, Kevin Anthony Macclesfield,Cheshire SK10 4TG (GB) (74) Representative: Phillips, Neil et al AstraZeneca AB,Global Intellectual Property 151 85 Sodertalje 151 85 Sodertalje (SE)