(19)

(11)

EP 1 240 324 A2

(12)

(88) Date of publication A3: 11.07.2002 (43) Date of publication: 18.09.2002 Bulletin 2002/38 (21) Application number: 00984377.2 (22) Date of filing: 14.12.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 16/28, G01N 33/68, C12Q 1/68, A61K 38/17, A61K 48/00, A61K 39/395, A61K 31/713 (86) International application number: PCT/US0033/909 (87) International publication number: WO 0104/4473 (21.06.2001 Gazette 2001/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.12.1999 US 170564 P 27.12.1999 US 173165 P 27.12.1999 US 173362 P 29.12.1999 US 173544 P 04.01.2000 US  09.08.2000 US 223929 P 13.12.2000 US  (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)	(72) Inventors: SPADERNA, Steven, K. Berlin, CN 06037 (US) QUINN, Kerry, E. Torrington, CT 06790 (US) SHIMKETS, Richard, A. West Haven, CT 06516 (US) PADRIGARU, Muralidhara Branford, CT 06405 (US) SPYTEK, Kimberley, A. New Haven, CT 06511 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)